Effect of tylophora asthmatica on hepatotoxicity induced by antitubercular drugs in albino rats

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Effect of Ocimum sanctum (OS) leaf extract on hepatotoxicity induced by antitubercular drugs in rats.

Healthy adult albino rats of either sex of Wistar strain weighing 150 to 250 g were used after approval of the Institutional Ethics Committee. They were kept on standard pellet diet and were allowed free access to food and water. The doses of antitubercular drugs (isoniazid (I)-27 mg/kg/day, rifampicin (R)-54 mg/kg/day, pyrazinamide (Z)-135 mg/kg/day) were extrapolated from daily human dose usi...

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Pharmacological considerations of Tylophora asthmatica

Tylophora asthmatica has recently been included as one of the important drug from natural source for the treatment of respiratory diseases. Clinical studies have shown effectiveness of the drug in bronchial asthma and thus modern research withstands the ancient claims of traditional medicine. This article reviews the various scientific studies and tries to analyze the current status of Tylophor...

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Effect of the antioxidants alpha-tocopherol acetate and sodium selenite on hepatotoxicity induced by antitubercular drugs in rats.

Blood samples of animals from groups I and II were taken for liver function tests by cardiac puncture under ether anaesthesia Hepatotoxicity due to antitubercular drugs is found to be mediated through oxidative stress and free radical damage to hepatocytes (1, 2, 3). The antioxidants α-tocopherol and selenium are known exert beneficial effect in antitubercular drugs induced hepatotoxicity (4, 5...

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Tylophora asthmatica Wight & Arn . - Review

Tylophora asthmatica is used in the treatment of respiratory diseases. In Ayurveda. Animal studies have demsonated antiasthmatic, anti-allergic, cytotoxic, hepatoprotective and immunomodulator activites of T.asthmatica. Secera clinical trials hev eebn carried out in case of bronchial asthma; however, design of most of these studies is convoluted. The monograph analyses chemistry, pharmacology a...

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ژورنال

عنوان ژورنال: International Journal of Basic and Clinical Pharmacology

سال: 2016

ISSN: 2319-2003

DOI: 10.18203/2319-2003.ijbcp20162442